Publication / 2024

Preparation and characterization of highly elongated polydimethylsiloxane nanosheets


Development of the observation of membrane fusion with label-free liposomes by calcium imaging


Evaluation of Stability and Cytotoxicity of Self-Doped PEDOT Nanosheets in a Quasi-Biological Environment for Bioelectrodes


Publication / 2023

Photothermal switch of drug release from polydopamine-modified nanosheets


Short-time total alveolar lavage for therapy of ARDS

  • Kenta Kakiuchi, Shinji Takeoka
  • Medical Science Digest, 2022, 48(1), p32-33

Do Ultrafine Bubbles Work as Oxygen Carriers?


Publication / 2022

Temperature-Responsive Liposome-Linked Immunosorbent Assay for the Rapid Detection of SARS-CoV‐2 Using Immunoliposomes


Sumac (Rhus coriaria) Extract-Loaded Polymeric Nanosheets Efficiently Protect Human Dermal Fibroblasts from Oxidative Stress


"H12-(ADP)-liposomes for hemorrhagic shock in thrombocytopenia: Mesenteric artery injury model in rabbits"


"End-Sealing of Peptide Nanotubes by Cationic Amphiphilic Polypeptides and Their Salt-Responsive Accordion-like Opening and Closing Behavior"


"Diospyros malabarica Fruit Extract Derived Silver Nanoparticles: A Biocompatible Antibacterial Agent"


"Arginine-based cationic liposomes accelerate T cell activation and differentiation in vitro"


"Angiogenic efficacy of ASC spheroids filtrated on porous nanosheets for the treatment of a diabetic skin ulcer"


"Paper-Based Wearable Ammonia Gas Sensor Using Organic–Inorganic Composite PEDOT:PSS with Iron(III) Compounds"


"Preparation and characterization of highly elongated polydimethylsiloxane nanosheets"


"Development of quantitative and concise measurement method of oxygen in fine bubble dispersion"


"H12-(ADP)-liposomes for hemorrhagic shock in thrombocytopenia: Mesenteric artery injury model in rabbits"

  • Kohsuke Hagisawa, Manabu Kinoshita, Shinji Takeoka, Osamu Ishida, Yayoi Ichiki, Daizoh Saitoh, Morihiro Hotta, MasatoTakikawa, lvo P. Torres Filho, Yuji Morimoto
  • Research and Practice in Thrombosis and Haemostasis, 2022, Vol.6, 2, https://onlinelibrary.wiley.com/doi/10.1002/rth2.12659

Publication / 2021

"Enhanced cellular engraftment of adipose-derived mesenchymal stem cell spheroids by using nanosheets as scaffolds"


"Flexible Film-Type Sensor for Electrochemical Measurement of Dopamine Using a Molecular Imprinting Method"


"Features and Development of Kirigami Structure Stretchable Wiring"

  • Sho Mihara, Shinji Takeoka
  • Plastics (Journal of the Japan Plastics Industry Federation), 2021-3, Vol.72 (123) p,5-9

"Angiogenic efficacy of ASC spheroids filtrated on porous nanosheets for the treatment of a diabetic skin ulcer"


導電性材料の設計、導電性制御および最新応用展開

  • 武岡真司、三原将、永田万桜
  • 技術情報協会, p.859-864

"Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid"

  • Izumi Kirino, Katsuhiko Fujita, Kei Sakanoue, Rin Sugita, Kento Yamagishi, Shinji Takeoka, Toshinori Fujie, Shinji Uemoto, Yuji Morimoto
  • Scientific Reports, (2020) 10:22017 , https://doi.org/10.1038/s41598-020-79067-7

"Fabrication of thermo-responsive cell-culture membranes with Poly(N-isopropylacrylamide) by electron-beam graft polymerization"


"Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures"

  • Asako Otomo, Mahoko Takahashi Ueda, Toshinori Fujie, Arihiro Hasebe, Yoshitaka Suematsu, Yosuke Okamura, Shinji Takeoka, Shinji Hadano, So Nakagawa
  • Scientific Reports, (2020) 10:6716, https://doi.org/10.1038/s41598-020-63537-z

"A Coupled FEM-SPH Modeling Technique to Investigate the Contractility of Biohybrid Thin Films"


"Development of a Non-IgG PD-1/PD-L1 Inhibitor by in Silico Mutagenesis and an In-Cell Protein–Protein Interaction Assay"


Publication / 2020

Characteristics of Functional Polymer Nanosheets and Applications in Bioelectronics Applications

  • Sinji Takeoka, Rin Sugita
  • Journal of the Japan Petroleum Institute

Enhanced in vitro magnetic cell targeting of doxorubicin-loaded magnetic liposomes for localized cancer therapy

  • Eugenio Redolfi Riva, Edoardo Sinibaldi, Agostina Francesca Grillone, Serena Del Turco, Alessio Mondini, Tianshu Li, Shinji Takeoka, Virgilio Mattoli2020, 10(11), 2104;
  • Nanomaterials,

A rapid and highly sensitive biomarker detection platform based on a temperature-responsive liposome-linked immunosorbent assay

  • Hu, R., Sou, K. & Takeoka, S.
  • Scientific Reports, 2020, 10.1: 1-11

Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes

  • Son, K., Ueda, M., Taguchi, K., Maruyama, T., Takeoka, S. & Ito, Y.
  • Journal of Controlled Release, https://doi.org/10.1016/j.jconrel.2020.03.022

Intracellular distribution of lipids and encapsulated model drugs from cationic liposomes with different uptake pathways

  • Takikawa, M., Fujisawa, M., Yoshino, K. & Takeoka, S
  • International Journal of Nanomedicine, 2020, 15: 8401-8409.

Therapeutic potential of fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes as a haemostatic adjuvant for post-cardiopulmonary bypass coagulopathy

  • Osamu Ishida, Kohsuke Hagisawa, Nozomu Yamanaka, Koji Tsutsumi, Hidenori Suzuki, Masato Takikawa, Shinji Takeoka, Manabu Kinoshita2020, 10.1: 1-11.
  • Scientific Reports,

Total alveolar lavage with oxygen fine bubble dispersion directly improves lipopolysaccharide-induced acute respiratory distress syndrome of rats

  • Kakiuchi, K., Miyasaka, T., Takeoka, S., Matsuda, K. & Harii, N.
  • Scientific Reports, 2020, 10.1: 1-10.

"Ultra-thin, transparent, porous substrates as 3D culture scaffolds for engineering ASC spheroids for high-magnification imaging"


Electrocardiogram measurements in water using poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) nanosheets waterproofed by polyurethane film

  • Sho Mihara, Hui-Lin Lee, Shinji Takeoka
  • MRS Communications Press: 01 October 2020, doi:10.1557/mrc.2020.72

In Vitro Delivery of Cell Impermeable Phallotoxin Using Cationic Liposomes Composed of Lipids Bearing Lysine Headgroup


In situ Transplantation of Adipose Tissue-Derived Stem Cells Organized on Porous Polymer Nanosheets for Murine Skin Defects

  • Keisuke Nishiwaki, Shimpo Aoki, Manabu Kinoshita, Tomoharu Kiyosawa, Yoshitaka Suematsu, Shinji Takeoka, Toshinori Fujie
  • Journal of Biomedical Materials Research Part B.

Graphene/Au Hybrid Antenna Coil Exfoliated with Multi-Stacked Graphene Flakes for Ultra-Thin Biomedical Devices

  • Yuma Tetsu, Yusuke Kido, Meiting Hao, Shinji Takeoka, Takeshi Maruyama, and Toshinori Fujie
  • Advanced Electronic Materials, in press

Publication / 2019

Elastic kirigami patch for electromyographic analysis of the palm muscle during baseball pitching

  • Kento Yamagishi, Takenori Nakanishi, Sho Mihara, Shinji Takeoka, Toshinori Fujie
  • NPG Asia Materials, (2019) 11:80

Sinter-free stretchable conductive inks composed of polystyrene-block-polybutadiene-block-polystyrene and silver flakes in tetrahydrofuran

  • T. Nakanishi, K. Yamagishi, E. Iwase, H. Iwata, S. Takeoka, T. Fujie
  • Applied Physics Express, 12, 075001 (2019)

Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency

  • Jieyan He, Tianshu Li, Tomasz Próchnicki,Gabor Horvath,Eicke Latz ,and Shinji Takeoka
  • Biochem Biophys Rep., 2019 Jul; 18: 100623.

NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells

  • Li T, Zehner M, He J, Próchnicki T, Horvath G, Latz E, Burgdorf S, Takeoka S
  • International Journal of Nanomedicine, 13 May 2019 Volume 2019:14 Pages 3503—3516

Biohybrid Actuators Based on Skeletal Muscle-Powered Microgrooved Ultrathin Films Consisting of Poly(styrene-blockbutadiene-block-styrene)

  • Arihiro Hasebe, Yoshitaka Suematsu, Shinji Takeoka, Tommaso Mazzocchi, Lorenzo Vannozzi, Leonardo Ricotti, and Toshinori Fujie
  • ACS Biomaterials Science & Engineering, DOI: 10.1021/acsbiomaterials.8b01550

Evaluation of Recently Discontinued Drugs to Identify Factors Contributing to their Failure and to Improve the Efficiency of Pharmaceutical Drug Development

  • K Ikeda, S Takeoka
  • Journal of Clinical Medicine and Therapeutics, 2018, Vol. 3, No. 1:4

Printed nanofilms mechanically conforming to living bodies

  • K Yamagishi, S Takeoka, T Fujie
  • Biomaterials Science, 10.1039/c8bm01290c

Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure

  • N Kokubo, M Arake, K Yamgishi, Y Morimoto, S Takeoka, H Ohta, T Fujie
  • ACS APPLIED BIO MATERIALS, 2019, 2 (1), pp 20–26

The Survey of Non-inferiority Trials for Cancer Drugs to Analyze Their Trends Including Guidelines

  • H Kiuchi, S Takeoka
  • レギュラトリーサイエンス学会誌, 2018 年 8 巻 3 号 p. 143-149

In situ transplantation of adipose tissue‐derived stem cells organized on porous polymer nanosheets for murine skin defects

  • K Nishiwaki, S Aoki, M Kinoshita, T Kiyosawa, Y Suematsu, S Takeoka, T Fujie
  • Society For Biomaterials, 10.1002/jbm.b.34228

Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

  • K Yanagishi, I Kirino, I Takahashi, H Amano, S Takeoka, Y Morimoto, T Fujie
  • Nature Biomedical Engineering, 3, pages27–36 (2019)

Amino acid-based liposomal assemblies: Intracellular plasmid DNA delivery nanoparticles

  • S Sarker, S Takeoka
  • Journal of Nanomedicine,

3 - Smart Liposomes for Drug Delivery

  • T Li, S Takeoka
  • Smart Nanoparticles for Biomedicine, 2018, Pages 31-47

Conductive Nanosheets for Ultra-Conformable Smart Electronics

  • K Yamagishi, S Taccola, S Takeoka, T Fujie, V Mattoli, F Greco
  • Flexible and Stretchable Medical Devices, 10.1002/9783527804856.ch11

Publication / 2018

Extracellular pH imaging of a plant leaf with a polyelectrolyte multilayered nanosheet

  • Someya, D., Arai, S., Takeoka, S., Fujie, T
  • RSC Adv, DOI: 10.1039/C8RA06308G

In situ Transplantation of Adipose Tissue-Derived Stem Cells Organized on Porous Polymer Nanosheets for Murine Skin Defects

  • Nishiwaki, K., Aoki, S., Kinoshita, M., Kiyosawa, T., Suematsu, Y., Takeoka, S., Fujie, T
  • J. Biomed. Mater. Res. B, DOI: 10.1002/jbm.b.34228

Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

  • Kento Yamagishi, Izumi Kirino, Isao Takahashi, Hizuru Amano, Shinji Takeoka, Yuji Morimoto, Toshinori Fujie
  • Nature Biomedical Engineering, DOI：1038/s41551-018-0261-7

Lysine-containing cationic liposomes activate the NLRP3 inflammasome: effect of a spacer between the head group and the hydrophobic moieties of the lipids.

  • Tianshu Li, Jieyan He, Gabor Horvath, Tomasz Prochnicki, Eicke Latz, Shinji Takeoka
  • Nanomedine: nanotechnology, biology and medicine, Volume14, 279-288(2018).

MEMS optical interferometry-based pressure sensor using elastomer nanosheet developed by dry transfer technique

  • Kazuhiro Takahashi, Toshinori Fujie, Nobutaka Sato, Shinji Takeoka, Kazuaki Sawada
  • Japanese Journal of Applied Physics, 57(1), (2018)

[Review] Amino acid-based liposomal assemblies: Intracellular plasmid DNA delivery nanoparticles.

  • Sarker SR, Takeoka S.
  • J Nanomed. 2018; 2: 1008.

[Book] Chapt 3, "Smart liposomes for drug delivery", Smart Nanoparticles for Biomedicine, Ed.Gianni Ciofani

  • Tianshu Li and Shinji Takeoka
  • Book ISBN: 9780128141571, Elsevier, (2018)

[Book] Conductive Nanosheets for Ultra-Conformable Smart Electronics

  • Kento Yamagishi, Silvia Taccola, Shinji Takeoka, Toshinori Fujie, Virgilio Mattoli, Francesco Greco
  • pp253-285 Flexible and Strechable Medical Devices, Ed. Kuniharu Takei, Wiley-VCH (2018)

Publication / 2017

Adhesive and robust multilayered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model

  • Komachi, T.a, Sumiyoshi, H.b, Inagaki, Y.b, Takeoka, S.c, Nagase, Y.a,
  • Journal of Biomedical Materials Research - Part B Applied Biomaterials, 105(7), 1747-1757(2017)

Construction of a new Cs+extraction process by using calix crown-containing magnetic nanoparticle-loaded fragmented nanosheets

  • Sato, K., Noguchi, G., Asao, K., Murata, A.a, Fujie, T.cd, Nagase, Y., Takeoka, S.
  • Kobunshi Ronbunshu, 74(2), 99-108(2017)

An elastomer-based MEMS fabry-perot interferometer for physical and biological sensing by dry transfer technique

  • Takahashi, K., Fujie, T., Sato, N., Takeoka, S., Sawada, K.
  • Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Article number 7863505, 704-707(2017)

Hybrid film for self-adhesion and shape-controlling

  • Shimbo, S., Fujie, T., Iwase, E.
  • Proc. 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS), 624-627(2017)

Thin polymeric films for building biohybrid microrobots.

  • Ricotti, L., Fujie, T.
  • Bioinspir. Biomim., 12, 021001(2017)

高分子ナノ薄膜とバイオ・エレクトロニクスの融合

  • 藤枝 俊宣, 武岡 真司
  • 化学と工業, 70(6), 494-496(2017)

Preparation, Characterization, and Preliminary In Vitro Testing of Nanoceria-Loaded Liposomes

  • Agostina Grillone, Tianshu Li, Matteo Battaglini, Alice Scarpellini, Mirko Prato, Shinji Takeoka and Gianni Ciofani
  • Nanomaterials, 7(9), 276(2017).

Ultrathin epidermal strain sensor based on an elastomer nanosheet with an inkjet-printed conductive polymer

  • Yuma Tetsu, Kento Yamagishi, Akira Kato, Yuya Matsumoto, Mariko Tsukune, Yo Kobayashi, Masakatsu G. Fujie, Shinji Takeoka and Toshinori Fujie
  • Applied Physics Express (APEX), 10, 087201(2017).

Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation

  • Kohei Kubota, Kohei Onishi, Kazuaki Sawaki, Tianshu Li, Kaoru Mitsuoka, Takaaki Sato, Shinji Takeoka
  • International Journal of Nanomedicine , 12, 5121-5133 (2017).

On the injectability of free-standing magnetic nanofilms

  • Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli
  • Biomedical Microdevices, 19: 51(2017).

Pore Clogging of Colloidal Mesoporous Silica Nanoparticles for Encapsulating Guest Species

  • Eisuke Yamamoto, Kouya Nagata, Kenta Onishi, Chihiro Urata, Atsushi Shimojima, Hiroaki Wada, Shinji Takeoka, and Kazuyuki Kuroda
  • Bulletin of the Chemical Society of Japan , 90, 706–708(2017).

生体組織に調和する高分子ナノシートの医療・ヘルスケアへの展開

  • 藤枝 俊宣, 山岸 健人, 武岡 真司.
  • 化学工業, 67(2)

肌に貼り付けるだけで生体情報をモニタリングする電子ナノ絆創膏

  • 山岸 健人, 武岡 真司, 藤枝 俊宣.
  • Biophilia, 5(4)

生体適合性高分子ナノシートの物性と医療応用

  • 武岡　真司
  • 医療用バイオマテリアルの研究開発, シーエムシー出版

カリックスクラウン誘導体からなる磁性ナノ粒子担持細断化ナノシート を用いたCs＋処理プロセスの構築

  • 佐藤 克典・野口 　元・浅尾 幸平・村田 　篤・藤枝 俊宣・長瀬 　裕・武岡 真司
  • 高分子論文集, 74 (2), 99-108(2017).

Construction and evaluation of pH-sensitive immunoliposomes for enhanced delivery of anticancer drug to ErbB2 over-expressing breast cancer cells

  • Tianshu Li, Takuya Amari, Kentaro Semba, Tadashi Yamamoto and Shinji Takeoka
  • Nanomedicine: Nanotechnology, Biology, and Medicine, 13, 1219–1227 (2017)

Printed high-frequency RF identification antenna on ultrathin polymer film by simple production process for soft-surface adhesive device

  • Hayata, H., Okamoto, M., Takeoka, S., Iwase, E., Fujie, T., Iwata, H.
  • Jpn. J. Appl. Phys, 56, 05EC01 (2017)

Optomechanical characterization of freestanding stretchable nanosheet based on polystyrene-poly- butadiene-polystyrene copolymer

  • Hayato Kumagai, Nobutaka Sato, Shinji Takeoka, Kazuaki Sawada, Toshinori Fujie and Kazuhiro Takahashi
  • Applied Physics Express, 10, 11601 (2017)

Development of Flexible Cell-Loaded Ultrathin Ribbons for Minimally Invasive Delivery of Skeletal Muscle Cells

  • Salehi, S., Ostrovidov, Serge., Ebrahimi, M., Sadeghian, R., Liang, X., Nakajima, K., Bae, H., Fujie, T., Khademhosseini, A.
  • ACS Biomater. Sci. Eng, , DOI: 10.1021/acsbiomaterials.6b00696 (2017)

Sandwich fixation of electronic elements using free-standing elastomeric nanosheets for low-temperature device processes.

  • Okamoto, M., Kurotobi, M., Takeoka, S., Sugano, J., Iwase, E., Iwata, H., Fujie, T
  • J. Mater. Chem. C,, 5, 1321-1327 (2017)

Publication / 2016

Fabrication and evaluation of freestanding stretchable nanosheet for optical MEMS application

  • Kumagai, H., Sawada, K., Takahashi, K., Sato, N., Takeoka, S., Fujie, T.
  • International Conference on Optical MEMS and Nanophotonics, 2016, 7565890(2016)

Development of a ubiquitously transferrable silver-nanoparticle-loaded polymer nanosheet as an antimicrobial coating

  • Ito, K., Saito, A., Fujie, T., Miyazaki, H.b, Kinoshita, M.c, Saitoh, D.b, , Ohtsubo, S., Takeoka, S.
  • Journal of Biomedical Materials Research - Part B Applied Biomaterials, 104(3), 585-593(2016)

Synthesis of Phosphorylcholine-Containing Polyimides and the Fabrication of Biocompatible Nanosheets Thereof

  • Asao, K., Ogino, M., Iwano, A., Okamura, Y., Takeoka, S., Nagase, Y.
  • Kobunshi Ronbunshu, 73(1), 76-86(2016)

医療応用を目的とした癒着防止ナノ絆創膏の可能性（第1章2節）」手術用シーラント材・癒着防止材の利便化向上を目指した製品開発

  • 木下 学, 檜 顕成, 藤枝 俊宣, 武岡 真司
  • 技術情報協会, 第1章第2節(2016)

Facilely Fabricated Luminescent Nanoparticle Thermosensor for Real-Time Microthermography in Living Animals

  • Ferdinandus, Satoshi Arai, Shinji Takeoka, Shin’ichi Ishiwata, Madoka Suzuk, and Hirotaka Sato
  • ACS Sensors, 1 (10), 1222–1227(2016).

Optomechanical characterization of freestanding stretchable nanosheet based on polystyrene-polybutadiene-polystyrene copolymer

  • Kumagai, H., Sato, N., Takeoka, S., Sawada, K., Fujie, T., Takahashi, H
  • Appl. Phys. Express., 10, DOI: 10.7567/APEX.10.011601, (2016)

Stretchable, adhesive and ultra-conformable elastomer thin films

  • N. Sato, A. Murata, T. Fujie, S. Takeoka
  •  Soft Matter, 12,  9202-9209, (2016)

Large-scale fabrication of porous polymer nanosheets for engineering hierarchical cellular organization

  • Shoichiro Suzuki, Keisuke Nishiwaki, Shinji Takeoka, Toshinori Fujie
  • Advanced Materials Technologies, 1, DOI:10.1002/admt.201600064, (2016)

Glue-Free Stacked Luminescent Nanosheets Enable High-Resolution Ratiometric Temperature Mapping in Living Small Animals

  • T. Miyagawa, T. Fujie, Ferdinandus, T. T. Vo Doan, H. Sato, S. Takeoka
  • ACS Applied Materials & Interfaces,  8 (49), 33377–33385, (2016)

Sheet shape-controlling method for hundreds-nanometer-thick　polymer film.

  • Shimbo, S., Fujie, T., Iwase, E.
  • Jpn. J. Appl. Phys, 55, 06GP21, (2016)

Interfacial Effects on the Crystallization and Surface Properties of Poly(L-lactic acid) Ultrathin Films.

  • Udagawa, A., Fujie, T., Kawamoto, Y., Saito, A., Takeoka, S., Asahi, T
  • Polymer J., 48, 157-161, (2016)

Facilely-fabricated luminescent nanoparticle thermosensor for real-time microthermography in living animals

  • Ferdinandus, Arai, S., Takeoka, S., Ishiwata, S., Suzuki, M. and Sato, H.
  • ACS Sensors, 1(10) , 1222 - 1227, (2016)

Focal calcium monitoring with targeted nanosensors at the cytosolic side of endoplasmic reticulum

  • Hou, Y., Arai, S., Takei, Y., Murata, A., Takeoka, S. and Suzuki, M.
  • Sci. Technol. Adv. Mater., 17(1), 293 - 299, (2016)

Phospholipase Cβ1 induces membrane tubulation and is involved in caveolae formation

  • T.Inaba, T.Kishimoto, M.Muratea, T.Tajima, S.Sakaia, M.Abe, A. Makino, N.Tomishige, R.Ishitsuka, Y.Ikeda, S.Takeoka, and T.Kobayashi
  • PNAS, 113(28), 7834–7839, (2016)

Fibrinogen -Chain PeptideCoated Adenosine 5' DiphosphateEncapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling

  • Hagisawa, K, Kinoshita, M, Miyawaki, H, Sato, S, Miyazaki, H, Takeoka, S, Suzuki, H, Iwaya, K, Seki, S, Shoji, S, Saitoh, D, Nishida, Y, Handa, M,
  • Crit.Care Med., , 44, e827–e837, (2016)

Massive Fabrication of Polymer Microdiscs by Phase Separation and Freestanding Process

  • H. Zhang, M. Fujii, Y. Okamura, L. Zhang, and S. Takeoka
  • ACS Appl. Mater. Interfaces, 8 (25), 16296–16302, (2016)

ホスホリルコリン基を有するポリイミドの合成と生体適合性ナノシートの作製

  • 浅尾 幸平, 荻野 真里, 岩野 篤, 岡村 陽介, 武岡 真司, 長瀬 裕
  • 高分子論文集, 73(1), 76-86 , (2016)

生体組織に調和する高分子ナノシートの医療・ヘルスケアへの展開

  • 藤枝 俊宣, 山岸 健人, 武岡 真司.
  • 化学工業,, 67(2) , 49-54, (2016)

Development of free-standing polymer nanosheets for advanced medical and healthcare applications

  • T. Fujie
  • Polymer Journal (Focus Review), in press, DOI:10.1038/pj.2016.38
  • リンク

Polylactic acid nanosheets in prevention of postoperative intestinal adhesion and their effects on bacterial propagation in an experimental model

  • A. Hinoki, A. Saito, M. Kinoshita, J. Yamamoto, D. Saitoh and S. Takeoka
  • British Journal of Surgery, 103(5) in press, DOI: 10.1002/bjs.10122

Publication / 2015

Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia

  • M.Hashimoto, K.Taguchi, S.Ogaki, H.Watanabe, M.Kinoshita, K.Nishikawa, S.Takeoka, Y.Ikeda, M.Handa, M.Otagiri, T.Maruyama
  • Journal of Pharmaceutical Sciences, 104, 3968-3976(2015)

Micro-thermography in millimeter-scale animals by using orally-dosed fluorescent nanoparticle thermosensors

  • S.Arai, Ferdinandus, S.Takeoka, S.Ishiwata, H.Sato, M.Suzuki
  • Analyst, 140, 7534-7539(2015)

「医療応用に向けた高分子ナノシートの開発（第26章）」進化する医療用バイオベースマテリアル

  • 藤枝 俊宣，武岡 真司
  • CMC出版, 251-263(2015)

Sustainable antimicrobial effect of silver sulfadiazine-loaded nanosheets on infection in a mouse model of partial-thickness burn injury


Patchwork Coating of Fragmented Ultra-Thin Films and Their Biomedical Applications in Burn Therapy and Antithrombotic Coating

  • Yosuke Okamura, Yu Nagase and Shinji Takeoka
  • Materials 2015, 8(11), 7604-7614; doi:10.3390/ma8115404
  • Link

Roll to roll processing of ultraconformable conducting polymer nanosheets

  • A. Zucca, K. Yamagishi, T. Fujie, S. Takeoka, V. Mattoli and F. Greco
  • J. Mater. Chem. C, 2015,3, 6539-6548
  • Link

A ratiometric fluorescent molecular probe for visualization of mitochondrial temperature in living cells

  • Homma M., Takei Y., Murata A., Inoue T., Takeoka S.
  • Chemical Communications, DOI: 10.1039/C4CC10349A
  • Link

Establishment of a total liquid ventilation system using saline-based oxygen micro/nano-bubble dispersions in rats

  • Kenta Kakiuchi, Kenichi Matsuda, Norikazu Harii, Keitaro Sou, Junko Aoki, Shinji Takeoka
  • Journal of Artificial Organs,(2015) 10.1007/s10047-015-0835-z
  • Link

A Cu-free clickable fluorescent probe for intracellular targeting of small biomolecules

  • Kento Yamagishi, Kazuaki Sawaki, Atsushi Murata and Shinji Takeoka
  • Chem. Commun., 2015,51, 7879-7882
  • Link

Treatment with fibrinogen γ-chain peptide-coated, adenosine 5′-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia

  • Kohsuke Hagisawa; Kahoko Nishikawa; Rempei Yanagawa; Manabu Kinoshita; Mami Doi; Hidenori Suzuki; Keiichi Iwaya; Daizoh Saitoh; Shuhji Seki; Shinji Takeoka; et al.
  • Transfusion. 2015;55(2):314-325.
  • Link

Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model

  • Kazuaki Taguchi; Mai Hashimoto; Shigeru Ogaki; Hiroshi Watanabe; Shinji Takeoka; Yasuo Ikeda; Makoto Handa; Masaki Otagiri; Toru Maruyama
  • Journal of Pharmaceutical Sciences,  (2015) in press. DOI: 10.1002/jps.24418
  • Link

Publication / 2014

Homeotropic alignment of dendritic columnar liquid crystal induced by hydrogen-bonded triphenylene core bearing fluoroalkyl chains

  • S.Ishihara, Y.Furuki, J.P.Hill, K.Ariga, S.Takeoka
  • Journal of Nanoscience and Nanotechnology, 14, 5130-5137(2014)

Myotube formation on gelatin nanofibers - multiwalled carbon nanotubes hybrid scaffolds.

  • Ostrovidov, S., Shi, X., Zhang, L., Liang, X., Kim, S-B., Fujie, T., Ramalingam, M., Chen, M., Nakajima, K., Al-Hazmi, F., Bae, H.,
  • Biomaterials, 35, 6268-6277(2014)

再生医療を指向したバイオニックナノ薄膜の創製

  • 藤枝 俊宣
  • 化学と工業, 67(11), 996-997(2014)

低侵襲な細胞移植療法に向けた微細パターン化高分子ナノシートの開発

  • 藤枝 俊宣
  • バイオマテリアル-生体材料-, 32(1), 35-38(2014)

ナノシートを活かした新しい医療材料：ナノ絆創膏の開発

  • 藤枝 俊宣
  • バイオサイエンスとインダストリー, 72(2), 127-129(2014)

細胞外マトリックスの構造と機能を規範とする高分子ナノシートの開発と組織工学への応用

  • 藤枝 俊宣
  • 機能材料, 34(1), 32-39(2014)

Nanobiotechnology (アレクサンダー・セイファリアン著) -Chapter 6: Development of Nanosheet Technology Toward Advanced Nanomedical Engineering

  • 藤枝俊宣，武岡真司
  • One Central Press, イギリス
  • Link

細胞外マトリックスを規範とする高分子ナノシートの創製と生体組織工学への応用

  • 藤枝 俊宣
  • 高分子論文集 71(9), 408-417 (2014)

Intracellular delivery of universal proteins using a lysine headgroup containing cationic liposomes: Deciphering the uptake mechanism

  • Satya Ranjan Sarker; Ryosuke Hokama; Shinji Takeoka
  • Molecular Pharmaceutics. 2014;11(1):164-174.
  • Link

Periosteum-mimetic structures made from freestanding microgrooved nanosheets.

  • Shi, X.*, Fujie, T.*, Saito, A., Takeoka, S., Hou, Y., Shu, Y., Chen, M.,Wu, H., Khademhosseini, A.
  • Adv. Mater. , 26, 3290-3296 (2014)
  • Link

Enhanced cellular uptake of maleimide-modified liposomes via thiol-mediated transport

  • Tianshu Li, Shinji Takeoka *
  • International Journal of Nanomedicine, 9, 2849-2861 (2014).
  • Link

A Nanoparticle-Based Ratiometric and Self-Calibrated Fluorescent Thermometer for Single Living Cells

  • Yoshiaki Takei, Satoshi Arai, Atsushi Murata, Masao Takabayashi, Kotaro Oyama, Shin’ichi Ishiwata, Shinji Takeoka, and Madoka Suzuki
  • ACS NANO 2014, 8 (1), pp 198–206
  • See this article

Publication / 2013

Arginine-based cationic liposomes for efficient in vitro plasmid DNA delivery with low cytotoxicity

  • S. R. Sarker, Y. Aoshima, R. Hokama, T. Inoue, K. Sou, and S. Takeoka
  • Int. J. Nanomedicine, 8,1361-1375(2013)

Intracellular click reaction with a fluorescent chemical Ca2+ indicator to prolong its cytosolic retention

  • Y. Takei, A. Murata, K. Yamagishi, S. Arai, H. Nakamura, T. Inoue, and S. Takeoka
  • Chem. Commun., 49,7313-7315(2013)

Cationic Amino Acid Based Lipids as Effective Non-viral Gene Delivery Vectors for Primary Cultured Neurons

  • Yumiko Aoshima, Ryosuke Hokama, Keitaro Sou, Satya Ranjan Sarker, Kabuto Iida, Hideki Nakamura, Takafumi Inoue, and Shinji Takeoka
  • ACS Chem. Neurosci., 4, 514–1519 (2013).
  • See this article

Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model.

  • Taguchi K, Ujihira H, Watanabe H, Fujiyama A, Doi M, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.
  • J.Pharm. Sci.,102,3852–3859 (2013).
  • See this article

Development of Latanoprost-Loaded Biodegradable Nanosheet as a New Drug Delivery System for Glaucoma

  • Kenji Kashiwagi, Keisuke Ito, Hiroki Haniuda, Shinya Ohtsubo, and Shinji Takeoka
  • Invest. Ophthalmol. Vis. Sci., 54, 5629-5637 (2013).
  • See this article

A novel application of maleimide for advanced drug delivery: In vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes

  • Tianshu Li, Shinji Takeoka
  • Int.J.Nanomed., 8, 3855-3866 (2013).
  • See this article

Pharmacokinetic Study of the Structural Components of Adenosine Diphosphate-encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute

  • Kazuaki Taguchi, Hayato Ujihira, Shigeru Ogaki, Hiroshi Watanabe, Atsushi Fujiyama, Mami Doi, Yosuke Okamura, Shinji Takeoka, Yasuo Ikeda, Makoto Handa, Masaki Otagiri, and Toru Maruyama
  • Drug Metabolism ＆ Disposition, June 2013, 41 (6) doi: 10.1124/dmd.112.050005
  • See this article

Effective control of massive venous bleeding by "multi-overlapping therapy" using polysaccharide nanosheets in a rabbit inferior vena cava injury model

  • Kohsuke Hagisawa, Akihiro Saito, Manabu Kinoshita, Toshinori Fujie, Naoki Otani, Satoshi Shono, Young-Kwang Park, and Shinji Takeoka
  • J.Vasc.Surg.: Venous and Lymphatic Disorders, 1, 289-297 (2013).
  • See this article

Tapping-mode AFM study of tip-induced polymer deformation under geometrical confinement

  • Hong Zhang; Yukio Honda; Shinji Takeoka
  • Langmuir, 29,1333-1339 (2013).
  • See this article

Application of poly-l-lactic acid nanosheet as a material for wound dressing

  • Shimpo Aoki; Manabu Kinoshita; Hiromi Miyazaki; Akihiro Saito; Toshinori Fujie; Keiichi Iwaya; Shinji Takeoka; Daizoh Saitoh
  • Plastic and Reconstructive Surgery. 131, 236-240 (2013).
  • See this article

Novel therapeutic use of polysaccharide nanosheets for arachnoid plasty and enhancement of venous tensile strength in rat microneurosurgery

  • Naoki Otani; Manabu Kinoshita; Toshinori Fujie; Akihiro Saito; Shinji Takeoka; Daizoh Saitoh; Kohsuke Hagisawa; Hiroshi Nawashiro; Katsuji Shima
  • J.Clinical Neurosci., 20,301-305 (2013).
  • See this article

Fragmentation of Poly(lactic acid) nanosheets and patchwork treatment for burn wounds

  • Yosuke Okamura; Koki Kabata; Manabu Kinoshita; Hiromi Miyazaki; Akihiro Saito; Toshinori Fujie; Shinya Ohtsubo; Daizoh Saitoh; Shinji Takeoka
  • Advanced Materials,25,545-551 (2013).
  • See this article

Selective molecular permeability induced by glass transition dynamics of semicrystalline polymer ultrathin films

  • Toshinori Fujie; Yuko Kawamoto; Hiroki Haniuda; Akihiro Saito; Koki Kabata; Yukio Honda; Eriko Ohmori; Toru Asahi; Shinji Takeoka
  • Macromolecules, 46,395-402 (2013).
  • See this article

Drift and fluctuating motion of artificial platelets during the lateral transport and adhesion process near the wall

  • Hiroaki Tobimatsu; Antoine Paragon; Yosuke Okamura; Shinji Takeoka; Ryo Sudo; Yasuo Ikeda; Kazuo Tanishita
  • J.Biorheology, 26,11-20 (2013).
  • See this article

Intracellular click reaction with a fluorescent chemical Ca2+ indicator to prolong its cytosolic retention

  • Yoshiaki Takei , Atsushi Murata , Kento Yamagishi , Satoshi Arai , Hideki Nakamura , Takafumi Inoue and Shinji Takeoka
  • Chem. Commun., 49, 7313-7315 (2013).
  • See this article

Application of nanosheets as an anti-adhesion barrier in partial hepatectomy

  • Daisuke Niwa, Masatsugu Koide, Toshinori Fujie, Nobuhito Goda, Shinji Takeoka*
  • J.Biomed.Mater.Res. B: Applied Biomaterials, 101,1251–1258 (2013).
  • See this article

Publication / 2012

Evaluation of the influence of ionization states and spacers in the thermotropic phase behaviour of amino acid-based cationic lipids and the transfection efficiency of their assemblies

  • S. R. Sarker, S. Arai, M. Murate, H. Takahashi, M. Takata, T. Kobayashi, S. Takeoka
  • International Journal of Pharmaceutics, 422(1-2),364-373(2012)

高分子系ナノシートの外科手術用創傷被覆材，癒着防止材としての可能性

  • 武岡 真司, 藤枝 俊宣
  • Material Stage, 12(7), 16-19(2012)

「高分子超薄膜（ナノシート）の外科手術用創傷被覆材（第2章第1節）」 先端バイオマテリアルハンドブック

  • 藤枝 俊宣, 武岡 真司
  • NTS, 267-272(2012)

生体投与可能なナノ構造体の構築と血小板代替物への応用

  • 岡村陽介、武岡真司
  • 人工血液 20 (2), 38-47(2012)

高分子系ナノシートの外科手術用創傷被覆材、癒着防止剤としての可能性

  • 武岡　真司、藤枝　俊宣
  • MATERIAL STAGE, 12(7), 16-19(2012)

Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets

  • Koji Tokutomi,Toshiaki Tagawa,Maki Korenaga,Masatoshi Chiba,Tomohiro Asai,Naohide Watanabe,Shinji Takeoka,Makoto Handa,Yasuo Ikeda,Naoto Okud
  • Int.J.Pharmaceutics, 438(1-2), 296 - 301 (2012)
  • See this article

Coordinative Nanoporous Polymers Synthesized with Hydrogen-Bonded Columnar Liquid Crystals

  • Shinsuke Ishihara,* Yusuke Furuki, Jonathan P. Hill, Katsuhiko Ariga, and Shinji Takeoka*
  • J. Nanosci. Nanotechnol., 12(10), 7885-7895 (2012)
  • See this article

Mass Spectrometric Screening of Ligand with Lower Off-rate from a Clikced-based Pooled Library

  • Arai, S.; Hirosawa, S.; Oguchi, Y.; Suzuki, M.; Murata, A.; Ishiwata, S.; Takeoka, S.
  • ACS Comb.Sci., 14, 451-455(2012)
  • See this article

Fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage

  • Nishikawa K, Hagisawa K, Kinoshita M, Shono S, Katsuno S, Doi M, Yanagawa R, Suzuki H, Iwaya K, Saitoh D, Sakamoto T, Seki S, Takeoka S, Handa M.
  • J. Thromb. Haemostasis, 10(10), 2137-2148(2012)
  • See this article

Therapeutic efficacy of an antibiotic-loaded nanosheet in a murine burn-wound infection model

  • A.Saito, H. Miyazaki, T. Fujie, M. Kinoshita, S. Ohtsubo, D. Saitoh, S. Takeoka
  • Acta Biomaterialia, 2012, 8, 2932-2940
  • See this article

Morphological evolution within spin-cast ultrathin polymer blend films clarified by a freestanding method

  • Hong Zhang; Shinji Takeoka
  • Macromolecules, 2012, 45(10), 4315-4321
  • See this article

A TEMPO-Conjugated Fluorescent Probe for Monitoring Mitochondrial Redox Reactions.

  • S. Hirosawa, S. Arai, S. Takeoka
  • Chemical communications, 48, 4845-4847(2012)
  • See this article

Walking nanothermometers: Spatiotemporal temperature measurement of transported acidic organelles in single living cells.

  • Kotaro Oyama, Masao Takabayashi, Yoshiaki Takei, Satoshi Arai, Shinji Takeoka, Sinichi Ishiwata, Madoka Suzuki
  • Lab on a chip, 12, 1591-1593(2012)
  • See this article

An ultra-thin poly(L-lactic acid) nanosheet as a burn-wound dressing for protection against bacterial infection.

  • Hiromi Miyazaki, Manabu Kinoshita, Akihiro Saito, Toshinori Fujie, Koki Kabata, Etsuko Hara, Satoshi Ono, Shinji Takeoka, Daizoh Saitoh
  • Wound Repair and Regeneration, 2012;20(4):573-579
  • See this article

Publication / 2011

Fabrication, Properties, and Biomedical Applications of Nanosheets

  • Fujie, T., Okamura, Y., Takeoka, S.
  • Functional Polymer Films , 2, 907-931(2011)

Gas bioengineering using hemoglobin-vesicles for versatile clinical applications

  • Sakai, H., Takeoka, S., Kobayashi, K.
  • Current Pharmaceutical Design , 17(22), 2352-2359(2011)

Intravenous infusion of Hb-vesicles (artificial oxygen carriers) after repetitive blood exchange with a series of plasma expanders (water-soluble biopolymers) in a rat model

  • Sakai, H., Miyagawa, N., Horinouchi, H., Takeoka, S., Takaori, M., Tsuchida, E., Kobayashi, K.
  • Polymers for Advanced Technologies , 22(8), 1216-1222(2011)

Aqueous colloidal mesoporous nanoparticles with ethenylene-bridged silsesquioxane frameworks.

  • Urata, C.; Yamada, H.; Wakabayashi, R.; Aoyama, Y.; Hirosawa, S.; Arai, S.; Takeoka, S.; Yamauchi, Y.; Kuroda, K.
  • J. Am. Chem. Soc., 133(21), 8102-8105(2011)
  • See this article

Fluorescent “Turn-on” system utilizing a quencher-conjugated peptide for specific protein labeling of living cells

  • Satoshi Arai, Su-In Yoon, Atsushi Murata, Masao Takabayashi, Xiaoyu Wu, Yixin Lu, Shinji Takeoka, Miwako Ozaki
  • Biochem. Biophys. Res. Commun., 1, 211-216(2011)
  • See this article

Chirality Sensing by Nonchiral Porphines

  • Jan Labuta, Shinsuke Ishihara, Atsuomi Shundo, Satoshi Arai Shinji Takeoka, Katsuhiko Ariga, Jonathan P. Hill
  • Chemistry - A European Journal, 17(13), 3558-3561(2011)
  • See this article

Increased viscosity of hemoglobin-based oxygen carriers retards no-binding when perfused through narrow gas-permeable tubes

  • Hiromi Sakai, Naoto Okuda, Shinji Takeoka, and Eishun Tsuchida
  • Microvascular Research, 81(2), 169-176(2011)
  • See this article

Free-Standing Poly(l-lactic acid) Nanofilms Loaded with Superparamagnetic Nanoparticles

  • Taccola S, Desii A, Pensabene V, Fujie T, Saito A, Takeoka S, Dario P, Menciassi A, Mattoli V
  • Langmuir, 27(9), 5589-5595 (2011)
  • See this article

Convenient method for surface modification by patching a freestanding anti-biofouling nanosheet

  • Toshinori Fujie , Hiroki Haniuda and Shinji Takeoka
  • J. Mater. Chem., 21, 9112-9120(2011)
  • See this article

A few immobilized thrombins are sufficient for platelet spreading

  • Okamura Y, Schmidt R, Raschke I, Hintze M, Takeoka S, Egner A, Lang T
  • Biophysical　Journal, 100(8), 1855-1863(2011)
  • See this article

Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets

  • Koji Tokutomi, Toshiaki Tagawa, Maki Korenaga, Masatoshi Chiba, Tomohiro Asai, Naohide Watanabe, Shinji Takeoka, Makoto Handa, Yasuo Ikeda, Naoto Oku
  • International Journal of Pharmaceutics, 407(1-2), 151-157(2011)
  • See this article

Heterofunctional nanosheet controlling cell adheasion properties by collagen coating

  • Niwa, D., Fujie, T., Lang, T., Goda, N., Takeoka, S.
  • J. Biomaterials Applications, 27(2), 131-141(2011)
  • See this article

Novel technique of overlaying a poly-l-lactic acid nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model

  • Keiichi. Fujino, Manabu. Kinoshita, Akihiro. Saitoh, Hidekazu. Yano, Kahoko. Nishikawa, Toshinori. Fujie, Keiichi. Iwaya, Minoru Kakihara, Shinji. Takeoka and Daizoh. Saitoh, Yuji. Tanaka
  • Surg. Endosc., 25(10), 3428-3436(2011)
  • See this article

Multiplex analysis of sphingolipids using amine-reactive tags (iTRAQ)

  • T．Nabetani,　A．Makino,　F．H. Matsuda，T. Hirakawa, S. Takeoka,　N. Okino,　M. Ito,　T. Kobayashi, Y. Hirabayashi
  • J. Lipid Research, 52, 1294-1302(2011)
  • See this article

Ultrastructural analysis of thrombin-induced interaction between human platelets　and liposomes carrying fibrinogen γ-chain dodecapeptide as a synthetic　platelet substitute

  • Hidenori Suzuki, Yosuke Okamura, Yasuo Ikeda, Shinji Takeoka, Makoto Handa
  • Thrombosis Research, 128(6), 552-559(2011)
  • See this article

Ultra-thin conductive free-standing PEDOT/PSS nanofilms

  • Francesco Greco, Alessandra Zucca, Silvia Taccola, Arianna Menciassi, Toshinori Fujie, Hiroki Haniuda, Shinji Takeoka, Paolo Dario, and Virgilio Mattoli
  • Soft Matter, 7, 10642-10650(2011)
  • See this article

Functional Polymer Films, Chapt 29 Fabrication, Properties, and Biomedical Applications of Nanosheets

  • Toshinori Fujie, Yosuke Okamura, Shinji Takeoka
  • WILEY－VCH(2011)

Publication / 2010

Evaluation of pH-responsive liposomes containing amino acid-based zwitterionic lipids for improving intracellular drug delivery in vitro and in vivo

  • Obata, Y., Tajima, S., Takeoka, S.
  • Journal of Controlled Release, 142(2), 267-276(2010)

Hemoglobin encapsulation in vesicles retards NO and CO binding and O2release when perfused through narrow gas-permeable tubes

  • Sakai, H., Okuda, N., Sato, A., Yamaue, T., Takeoka, S., Tsuchida, E.
  • American Journal of Physiology - Heart and Circulatory Physiology, 298(3), H956-H965(2010)

Drift and fluctuating motion of artificial platelet during adhesion process near the wall

  • Tobimatsu, H., Paragon, A., Okamura, Y., Takeoka, S., Sudo, R., Tanishita, K.
  • IFMBE Proceedings, 31 IFMBE, 1075-1078(2010)

医療応用に向けた高分子超薄膜の新展開

  • 藤枝 俊宣, 齋藤 晃広, 武岡 真司
  • 表面, 48(7), 211-219(2010)

外科手術用創傷被覆材(ナノシート)

  • 木下 学, 藤枝 俊宣
  • 化学と教育, 58, 570-573(2010)

Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane flexibilities properties and their hemostatic effects as a platelet substitute.

  • Okamura, Y., Katsuno, S., Suzuki H., Maruyama, H., Handa, M., Ikeda, Y., Takeoka, S.
  • S.Journal of Controlled Release(2010)

Construction of a "turn-on" fluorescent probe system for His-tagged proteins.

  • Murata, A., Arai, S., Su-In, Y., Takabayashi, M., Ozaki, M., Takeoka, S.
  • Bioorganic & Medicinal Chemistry Letters(2010)

高分子超薄膜(ナ ノシート)の医用材料としての展開

  • 藤枝 俊宣, 武岡 真司
  • 高分子, 59 (12), 2010

Adhesion and proliferation of skeletal muscle cells on single layer poly(lactic acid) ultra-thin films.

  • Ricotti, L., Taccola, S., Pensabene, V., Mattoli, V., Fujie, T., Takeoka, S., Menciassi, A., Dario, P.
  • Biomed Microdevices, 12, 809-819 (2010)

Synthesis and Self-Assembling Behavior of a Porphyrin Bearing Multiple meso- Conjugated Barbiturates.

  • Arai, S., Okamura, T., Takeoka, S.
  • Tetrahedron Letters,51 (39)/,5177-5180

A Nano-Fibrous Assembly of Collagen / Hyaluronic Acid for Controlling Cell- Adhesive Properties.

  • T. Fujie, S. Furutate, D. Niwa, S. Takeoka
  • Soft Matter, 6, 4672-4676 (2010)

Dual therapeutic action of antibiotic-loaded nanosheets for the treatment of gastrointestinal tissue defects.

  • T. Fujie, A. Saito, K. Kinoshita, H. Miyazaki, S. Ohtsubo, D. Saitoh, S. Takeoka
  • Biomaterials, 31, 6269 -6278(2010)

Sealing effect of a polysaccharide nanosheet for murine cecal puncture.

  • Fujie, T., Kinosita, M., Shono, S., Saito, A., Okamura, Y., Saitoh, D., Takeoka, S.
  • Surgery, 148, 48-58 (2010)

「～体内組織に 『癒着しない』～ナノシートからなる手術用フィルムの開発」

  • 藤枝 俊宣, 松谷 哲行, 木下 学, 武岡 真司
  • Material Stage, 10(4), 4-6 (2010)

「穿孔性腹膜炎 に対するナノシートの応用」

  • 藤枝 俊宣, 木下 学, 齋藤 大蔵, 武岡 真司
  • Surgery Frontier,17(2), 37-43 (2010)

肺瘻修復におけ る超薄膜状ナノバイオマテリアルの臨床応用へ向けた基礎的検討

  • 松谷哲 行、藤枝俊宣、木下学、尾関雄一、武岡真司
  • 日本 呼吸器外科会雑誌(JACSURG), 1, 2-7 (2010)

Evaluation of cationic liposomes composed of an amino acid-based lipid for neuronal transfection.

  • Y. Obata, G. Ciofani, S. Raffa, A. Cuschieri, A. Menciassi, P. Dario, S. Takeoka
  • Nanomedicine: Nanotechnology, Biology, and Medicine, 6, 70-77 (2010)

Visualization of Liposomes Carrying Fibrinogen γ-Chain Dodecapeptide Accumulated to Sites of Vascular Injury Using Computed Tomography

  • Y. Okamura, K. Eto, H. Maruyama, M. Handa, Y. Ikeda, S. Takeoka
  • Nanomedicine: Nanotechnology, Biology, and Medicine, 6(2), 391-396 (2010)

Publication / more

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