An original article written by Dr, Tianshu Li, Jieyan He and Prof. Shinji Takeoka was published in Nanomedicine.
"Lysine- containing cationic liposomes activate the NLRP3 inflammasome: effect of a spacer between the head group and the hydrophobic moieties of the lipids."
"Tianshu Li, Jieyan He, Gabor Horvath, Tomasz Prochnicki, Eicke Latz, Shinji Takeoka"


Kohei Onishi, Genki Komakine, Hiroto Sato, Kon Son presented recent works in The Society of Blood Substitutes (12/7-8, 2017 , Tokyo, Japan)

S2 "The effect of nanoformulation of nucleic acid and lipid assemblies on cellular uptake" (Kohei Onishi)
S20 "Preparation of ADP-encapsulating liposomes with ethanol injection method" (Genki Komakine)
S19 "Recovery test from total lipuid ventilation with oxygen micro nano bubble solution to gas ventilation" (Hiroto Sato)
S21 "Evasion of Accelerated Blood Clearance Phenomenon by Polysarcosine Coating of Liposomes" (Kon Son)


Toshinori Fujie, Nana Kokubo and Keiko Nakahara presented recent works in The 39th Annual Meeting of the Japanese Society for Biomaterials (11/20-21, 2017, TOWER HALL FUNABORI, Japan)

1A-SL2 "Development of Printed Nanofilms for Bio-Monitoring and Controlling System" (Toshinori Fujie)
1P-124 "Development of Ultra-Thin Electrodes by Inkjet Printing and Measurment of Neuronal Signals" (Nana Kokubo)
1P-091 "Evaluation method of binding ability of liposomes to activated platelets by fluorescence labeling method" (Keiko Nakahara)


Assist. Prof. Toshinori Fujie received The Award for Young Investigator of Japanese Society for Biomaterials (2017).


Toshinori Fujie and Kento Yamagishi will present recent works in 2017 MRS Fall Meeting & Exhibit (11/26-12/1, 2017, Boston)

BM09.02.04 "An ultrathin epidermal strain sensor constructed with an inkjet-printed conductive polymer on an elastomer nanosheet" (Kento Yamagishi)
BM06.02.04 "Ratiometric Temperature Mapping of Living Tissues Using Ultra-Conformable Polymer Nanosheets Loading Thermo-Sensitive Dyes" (Toshinori Fujie)

Message from Prof. TAKEOKA

Welcome to Takeoka Laboratory. Our Lab studies biomolecular assembling sciences for nano-medicine. Molecular assembling and cooperative phenomena of biomolecules and/or biomacromolecules give us useful implications to construct smart nanodevices having multi-functions for biomedical application (Nano-medicine). Our research group quests the molecular assembling science and engineering of amphiphilic molecules such as phospholipids, glycolipids, aminolipids, and polyethyleneglycol (PEG)-lipids interacted with biomacromoleucles such as bioactive compounds, genes or proteins, in order to design and construct the nanocarriers in biomedical applications such as controlled drug delivery and release systems.

Research Topics

Nanosheet Group

Development of a free-standing ultra-thin and biocompatible polymer nanosheets

Imaging Group

To reveal a lot of unknown cellular activities, we are constructing novel fluorescent probes for bio-imaging

Liposome Group

Liposome should be multi-functional platform for drug delivery system

Platelet Group

Liposome based artificial platelets could promote platelet aggregation