• 

• Yu Oba "Research on metronomic photodynamic therapy using implantable light-emitting device with polydopamine-modified nanosheets"
• Shuhei Kitahara "Application of cross-linked chitosan aerogel intestinal anatomosis"

• 

• "Photothermal switch of drug release from polydopamine-modified nanosheets"
• Ken Shimizu, Shinji Takeoka
• Link

• Sung Wenhan"Development of CRISPR/Cas9 plasmid DNA lipid nanoparticles using lysine-based cationic lipids"
• Link

• Yan Chen"MXene-based Flexible Polymer Nanosheets for Thermotherapy"
• Link

• "Short-time total alveolar lavage for therapy of ARDS"
• Kenta Kakiuchi, Shinji Takeoka, Norikazu Harii

• Kenta Kakiuchi, ""Do finebubbles work as oxygen carriers?"

• Kenta Kakiuchi, "Establishment of oxygen measurement method for fine bubbles dispersion and evaluation of fine bubbles as oxygen carriers"
• Kengo Hayase, "The observation of the interaction between cationic liposomes and cells by calcium imaging"

• Hiroaki Taniguchi, "Fabrication of Free-standing Nanosheet with Self-doped PEDOT and Evaluation of Its Properties"

• "Do Ultrafine Bubbles Work as Oxygen Carriers?""
• Kenta Kakiuchi, Tomoki Kozuka, Nobuyuki Mase, Takehiro Miyasaka, Norikazu Harii, Shinji Takeoka

• December 2022/January 2023, 18, 12, p.26-31

• "Temperature-Responsive Liposome-Linked Immunosorbent Assay for the Rapid Detection of SARS-CoV‐2 Using Immunoliposomes"
• Runkai Hu, Morihiro Hotta, Taro Maruyama, Mizuki Fujisawa, Keitaro Sou, and Shinji Takeoka

• URL

• Kenta Kakiuchi, "Evaluation of physical properties of oxygen fine bubbles as oxygen carriers"
• Morihiro Hotta, "Observation of interaction between liposomes and cells by calcium imaging"

• URL

• "Sumac (Rhus coriaria) Extract-Loaded Polymeric Nanosheets Efficiently Protect Human Dermal Fibroblasts from Oxidative Stress"
• Melis Emanet, Mayu Okuda, Özlem Şen, Chiara Lavarello, Andrea Petretto, Shinji Takeoka, Gianni Ciofani
• URL

• "H12-(ADP)-liposomes for hemorrhagic shock in thrombocytopenia: Mesenteric artery injury model in rabbits"
• Kohsuke Hagisawa, Manabu Kinoshita, Shinji Takeoka, Osamu Ishida, Yayoi Ichiki, Daizoh Saitoh, Morihiro Hotta, Masato Takikawa, Ivo P. Torres Filho, Yuji Morimoto
• URL

• "End-Sealing of Peptide Nanotubes by Cationic Amphiphilic Polypeptides and Their Salt-Responsive Accordion-like Opening and Closing Behavior"
• Kon Son, Shinji Takeoka, Yoshihiro Ito, Motoki Ueda
• URL

• "Diospyros malabarica Fruit Extract Derived Silver Nanoparticles: A Biocompatible Antibacterial Agent"
• Shakil Ahmed Polash, Amir Hamza, Md Monir Hossain, Mehedi Hasan Tushar, Masato Takikawa, Razib Datta Shubhra, Noshin Saiara, Tanushree Saha, Shinji Takeoka, Satya Ranjan Sarker
• URL

• "Arginine-based cationic liposomes accelerate T cell activation and differentiation in vitro"
• Tianshu Li, Felix Tolksdorf, Wenhan Sung, Hiroto Sato, Felix J. Eppler, Morihiro Hotta, Waldemar Kolanus, Shinji Takeoka
• URL

• "Angiogenic efficacy of ASC spheroids filtrated on porous nanosheets for the treatment of a diabetic skin ulcer"
• Yoshitaka Suematsu, Hisato Nagano, Tomoharu Kiyosawa, Shinji Takeoka, Toshinori Fujie
• URL

• URL

• URL

• "Paper-Based Wearable Ammonia Gas Sensor Using Organic–Inorganic Composite PEDOT:PSS with Iron(III) Compounds"
• Fujita Hajime, Meiting Hao, Shinji Takeoka, Yuji Miyahara, Tatsuro Goda, Toshinori Fujie

• "Enhanced cellular engraftment of adipose-derived mesenchymal stem cell spheroids by using nanosheets as scaffolds"
• Hisato Nagano, Yoshitaka Suematsu, Megumi Takuma, Shimpo Aoki, Ayano Satoh, Eiji Takayama, Manabu Kinoshita, Yuji Morimoto, Shinji Takeoka, Toshinori Fujie , Tomoharu Kiyosawa

• "Preparation and characterization of highly elongated polydimethylsiloxane nanosheets"
• Sho Mihara, Shinji Takeoka

• "Flexible Film-Type Sensor for Electrochemical Measurement of Dopamine Using a Molecular Imprinting Method"
• Takumi Kishi, Toshinori Fujie, Hiroyuki Ohta, Shinji Takeoka

• "Development of quantitative and concise measurement method of oxygen in fine bubble dispersion"
• Kenta Kakiuchi, Takehiro Miyasaka, Norikazu Harii, Shinji Takeoka

• "Collaboration in Research and Education: Profs Gianni Ciofani and Shinji Takeoka lead a revolution in biomaterials"
• Shinji Takeoka

• "H12-(ADP)-liposomes for hemorrhagic shock in thrombocytopenia: Mesenteric artery injury model in rabbits"
• Kohsuke Hagisawa, Manabu Kinoshita, Shinji Takeoka, Osamu Ishida, Yayoi Ichiki, Daizoh Saitoh, Morihiro Hotta, MasatoTakikawa, lvo P. Torres Filho, Yuji Morimoto

• "Heat evaluation of polydopamine-modified nanosheets and application to drug release control"
• Ken Shimizu

• "Features and Development of Kirigami Structure Stretchable Wiring"
• Sho Mihara, Shinji Takeoka

• "Design of biomaterials to cover the incision by understanding the information of intestinal tissues" (Mayu Okuda)

• "Design of aligned porous chitosan hydrogel as a dressing to prevent anastomotic leakage"" (Mayu Okuda)

• "Investigation of preparation conditions for drug-encapsulated liposomes using microfluidic devices by multiple regression analyzes" (Syuntarou Uehara)

• "Fundamental property of fine bubble dispersion as an oxygen carrier" (Kenta Kakiuchi)
• "Evaluation of Cationic Liposomes on Inducing Calcium Mobilization in THP-1 Cells" (Aya Kitanaka)

• "Angiogenic efficacy of ASC spheroids filtrated on porous nanosheets for the treatment of a diabetic skin ulcer"
• Yoshitaka Suematsu, Hisato Nagano, Tomoharu Kiyosawa, Shinji Takeoka, Toshinori Fujie

• "Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid"
• Izumi Kirino, Katsuhiko Fujita, Kei Sakanoue, Rin Sugita, Kento Yamagishi, Shinji Takeoka, Toshinori Fujie, Shinji Uemoto, Yuji Morimoto

• "Fabrication of thermo-responsive cell-culture membranes with Poly(N-isopropylacrylamide) by electron-beam graft polymerization"
• Ryoya Shimura, Yoshitaka Suematsu, Hiroto Horiuchi, Shinji Takeoka, Akihiro Oshima, Masakazu Washio

• "Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures"
• Asako Otomo, Mahoko Takahashi Ueda, Toshinori Fujie, Arihiro Hasebe, Yoshitaka Suematsu, Yosuke Okamura, Shinji Takeoka, Shinji Hadano, So Nakagawa

• "A Coupled FEM-SPH Modeling Technique to Investigate the Contractility of Biohybrid Thin Films"
• Asako Otomo, Mahoko Takahashi Ueda, Toshinori Fujie, Arihiro Hasebe, Yoshitaka Suematsu, Yosuke Okamura, Shinji Takeoka, Shinji Hadano, So Nakagawa

• A26-1am-06 Development of waterproof bioelectrode using polyethylenedioxythiophene : polystyrenesulfonate (PEDOT:PSS) nanosheets and electrocardiogram measurements during bathing. (Sho Mihara)

• Development of a Non-IgG PD-1/PD-L1 Inhibitor by in Silico Mutagenesis and an In-Cell Protein-Protein Interaction Assay
• Boyang Ning, Xueli Ren, Kyoji Hagiwara, Shinji Takeoka, Yoshihiro Ito, Hideyuki Miyatake

• "Characteristics of Functional Polymer Nanosheets and Applications in Bioelectronics Applications"
• Shinji Takeoka, Rin Sugita

• "Enhanced in vitro magnetic cell targeting of doxorubicin-loaded magnetic liposomes for localized cancer therapy"
• Eugenio Redolfi Riva, Edoardo Sinibaldi, Agostina Francesca Grillone, Serena Del Turco, Alessio Mondini, Tianshu Li, Shinji Takeoka, Virgilio Mattoli

• "A rapid and highly sensitive biomarker detection platform based on a temperature-responsive liposome-linked immunosorbent assay"
• Hu, R., Sou, K. & Takeoka, S.

• "Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes"
• Son, K., Ueda, M., Taguchi, K., Maruyama, T., Takeoka, S. & Ito, Y.

• "Intracellular distribution of lipids and encapsulated model drugs from cationic liposomes with different uptake pathways"
• Takikawa, M., Fujisawa, M., Yoshino, K. & Takeoka, S

• "Therapeutic potential of fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes as a haemostatic adjuvant for post-cardiopulmonary bypass coagulopathy"
• Osamu Ishida, Kohsuke Hagisawa, Nozomu Yamanaka, Koji Tsutsumi, Hidenori Suzuki, Masato Takikawa, Shinji Takeoka, Manabu Kinoshita

• "Total alveolar lavage with oxygen fine bubble dispersion directly improves lipopolysaccharide-induced acute respiratory distress syndrome of rats"
• Kakiuchi, K., Miyasaka, T., Takeoka, S., Matsuda, K. & Harii, N.

• "In Vitro Delivery of Cell Impermeable Phallotoxin Using Cationic Liposomes Composed of Lipids Bearing Lysine Headgroup"
• Satya Ranjan Sarker, Masato Takikawa, Shinji Takeoka

• "Electrocardiogram measurements in water using poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) nanosheets waterproofed by polyurethane film"
• Sho Mihara, Hui-Lin Lee, Shinji Takeoka

• "Ultra-thin, transparent, porous substrates as 3D culture scaffolds for engineering ASC spheroids for high-magnification imaging"
• Yoshitaka Suematsu, Ya An Tsai, Shinji Takeoka, Clemens M. Franz, Satoshi Arai and Toshinori Fujie

• Graphene/Au Hybrid Antenna Coil Exfoliated with Multi-Stacked Graphene Flakes for Ultra-Thin Biomedical Devices

• Nanosheet electronics × Sports science (Sho Mihara)

• Efficacy of novel material for surface electromyography (Sho Mihara)

• "Elastic kirigami patch for electromyographic analysis of the palm muscle during baseball pitching"
• Kento Yamagishi, Takenori Nakanishi, Sho Mihara, Shinji Takeoka, Toshinori Fujie

• P2-32 Development of Flexible Antenna Coils for Gas Sensing Application (Meiting Hao)

• P87 "Preparation of spheroid-carried porous nanosheets for the treatment of diabetic murine skin defects"(Yoshitaka Suematsu)
• P109 "Development of bio-adhesive nanosheets for stable fixation of a small light source to deeply located organs" (Rin Sugita)

• P-14 Total liquid ventilation with oxygen fine bubbles for acute lung injury (Kenta Kakiuchi)
• Oral Presentation (session 3)Development of High-Sensitive and Rapid Biomolecule Detection Method by Using Temperature-resposive Fluorescent Liposomes (Hu Runkai)
• P-22 Preparation of anionic liposomes encapsulating FITC-Dextran in microfluidic device for multivariate analyses (Morihiro Hotta)
• P-17 Effect of Cationic Lipid Structure on Cellular Membrane Fusion Behavior of Cationic Liposomes (Mizuki Fujisawa)

• PE08-5 Total Liquid Ventilation with Oxygen Fine Bubble Dispersion Prevents from Acute Lung Injury in Rats (Kenta Kakiuchi)

• P245 TOTAL LIQUID VENTILATION WITH OXYGEN MICRO/NANO BUBBLE DISPERSED SALINE PREVENTS FROM LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY IN RATS (Kenta Kakiuchi)

• "Sinter-free stretchable conductive inks composed of polystyrene-block-polybutadiene-block-polystyrene and silver flakes in tetrahydrofuran"
• Takenori Nakanishi, Kento Yamagishi, Shinji Takeoka, Toshinori Fujie

• "Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency"
• Jieyan He, Tianshu Li, Tomasz Próchnicki,Gabor Horvath,Eicke Latz ,and Shinji Takeoka

• 1M12 "Fission of rod-shaped vesicle by rearrangement of component amphiphilic polypeptides" (Kon Son)
• 2Pe049 "Directed self-deployment of the thin film emission device by selective coating of fluoropolymer" (Meiting Hao)

• "NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells"
• Li T, Zehner M, He J, Próchnicki T, Horvath G, Latz E, Burgdorf S, Takeoka S

• "Biohybrid Actuators Based on Skeletal Muscle-Powered Microgrooved Ultrathin Films Consisting of Poly(styrene-blockbutadiene-block-styrene)"
• Arihiro Hasebe, Yoshitaka Suematsu, Shinji Takeoka, Tommaso Mazzocchi, Lorenzo Vannozzi, Leonardo Ricotti, Toshinori Fujie

• Oral presentation(session 1)Establishment of Total Liquid Ventilation System using Oxygen Micro/Nano Bubble Dispersion

• 1H18 "Development of thin film antenna coil consisting of organic polymer thin film using inkjet printing"

• "Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure"
• N Kokubo, M Arake, K Yamgishi, Y Morimoto, S Takeoka, H Ohta, T Fujie

• "In situ Transplantation of Adipose Tissue-Derived Stem Cells Organized on Porous Polymer Nanosheets for Murine Skin Defects"
• Keisuke Nishiwaki, Shimpo Aoki, Manabu Kinoshita, Tomoharu Kiyosawa, Yoshitaka Suematsu, Shinji Takeoka, Toshinori Fujie

• "Extracellular pH imaging of a plant leaf with a polyelectrolyte multilayered nanosheet"
• Daichi Someya, Satoshi Arai, Toshinori Fujie, Shinji Takeoka

• Invited 6-2　Printed nanofilms for wearable and implantable devices (Toshinori Fujie)
• ME-P31　Development of sinter-free stretchable conductive inks (Takenori Nakanishi)

• Ultra-thin Flexible Electronics for Healthcare Applications (Yusuke Kido)

• 2B-16 "Local Photodynamic Therapy by Bio-Adhesive Optoelectronics" (Toshinori Fujie)
• 1B-02 "Preparation of physically-tailored nanosheets for engineering spheroids" (Yoshitaka Suematsu)

• P11　Au/Graphene hybrid antenna coils for the flexible wireless electronics (Yuma Tetsu)
• B22　Fission of Dumbell-Shaped Vesicle Triggered by reconstruction of amphiphilic peptide packing (Kon Son)

• V-2 "Elucidation of the binding ability mechanism between liposomes and platelet" (Keiko Nakahara)
• V-3 "Evaluation of binding ability of anionic liposomes to activated platelet" (Mamoru Nishiura)
• V-1 "Effect of GSSG-liposomes on LPS stimulated macrophage-like cells" (Kazuma Yoshino)

• 18p-211A-14 "Development of an inkjet-printed thin film heater for medical application" (Yusuke Kido)

• 1T13 "Tissue-adhesive nanofilms for implantable device applications" (Toshinori Fujie)
• 1W19 "Development of inkjet-printed, polymeric ultra-thin neural microelectrodes for spike recording and optogenetics" (Nana Kokubo)
• 2Pf074 "Preparation of polydopamine-modified polycaprolactone nanosheets for intestinal anastomosis" (Isao Takahashi)
• 3ESA03 "Fission of dumbbell-shaped vesicle triggered by reconstruction of amphiphilic peptide packing" (Kon Son)
• 1Pd066 "Development of sinter-free printable stretchable conductive inks" (Takenori Nakanishi)

• "Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy"
• Kento Yamagishi, Izumi Kirino, Isao Takahashi, Hizuru Amano, Shinji Takeoka, Yuji Morimoto, Toshinori Fujie
• 早大プレスリリース
• DIGITAL TRENDS
• mail Online
• NewScientist

• Link

• 17p-F306-6 "Injectable Neural Electrodes on Flexible Polymer Nanosheets" (Toshinori Fujie)
• 18a-A204-9 "Development of inkjet-printed thin film antenna coil consisting of graphene flake" (Yuma Tetsu)
• 17p-P6-33 "Development of the inkjet-printed thin film heater for the wireless heater" (Yusuke Kido)
• 18a-A204-5 "Development of elastomer/metal particle-composited sinter-free printable, stretchable conductive inks" (Takenori Nakanishi)

• "Lysine- containing cationic liposomes activate the NLRP3 inflammasome: effect of a spacer between the head group and the hydrophobic moieties of the lipids."
• "Tianshu Li, Jieyan He, Gabor Horvath, Tomasz Prochnicki, Eicke Latz, Shinji Takeoka"

• S2 "The effect of nanoformulation of nucleic acid and lipid assemblies on cellular uptake" (Kohei Onishi)
• S20 "Preparation of ADP-encapsulating liposomes with ethanol injection method" (Genki Komakine)
• S19 "Recovery test from total lipuid ventilation with oxygen micro nano bubble solution to gas ventilation" (Hiroto Sato)
• S21 "Evasion of Accelerated Blood Clearance Phenomenon by Polysarcosine Coating of Liposomes" (Kon Son)

• 1A-SL2 "Development of Printed Nanofilms for Bio-Monitoring and Controlling System" (Toshinori Fujie)
• 1P-124 "Development of Ultra-Thin Electrodes by Inkjet Printing and Measurment of Neuronal Signals" (Nana Kokubo)
• 1P-091 "Evaluation method of binding ability of liposomes to activated platelets by fluorescence labeling method" (Keiko Nakahara)

• BM09.02.04 "An ultrathin epidermal strain sensor constructed with an inkjet-printed conductive polymer on an elastomer nanosheet" (Kento Yamagishi)
• BM06.02.04 "Ratiometric Temperature Mapping of Living Tissues Using Ultra-Conformable Polymer Nanosheets Loading Thermo-Sensitive Dyes" (Toshinori Fujie)

• 2Z14 Inkjet-printed conductive lines on polymer nanosheets towards the application of neuronal electrodes.(Toshinori Fujie)
• 1ESB10 Enhanced adhesive property of polymer nanosheets to biological tissue by polydopamine modification (Isao Takahashi)

• Application of micro/nano bubble dispersion for total liquid ventilation

• 6p-C11-4 "The development of ultrathin epidermal strain sensor with an inkjet-printed conductive polymer" (Yuma Tetsu)

• 2750615 "Thermo-sensitive dye laden polymer nanosheets for ratiometric temperature mapping of living muscle tissues." (Toshinori Fujie)
• COLL 219 "Directed contraction of microgrooved nanosheets powered by engineered myotubes under electrical stimulation." (Arihiro Hasebe)

• "Ultrathin epidermal strain sensor based on an elastomer nanosheet with an inkjet-printed conductive polymer"
• Yuma Tetsu, Kento Yamagishi, Akira Kato, Yuya Matsumoto, Mariko Tsukune, Yo Kobayashi, Masakatsu G. Fujie, Shinji Takeoka and Toshinori Fujie
• Link

• Presentation No. "Title" (Presenter)
• 1P-368" Development of Ultra-Thin Electrodes by Inkjet Printing for Measuring Neuronal Signals" (Nana Kokubo)

• 1-E-23 Evaluation of rescue effect of resuscitative transfusion using platelet substitute, H12-(ADP)liposomes (Masato Takikawa)
• 1-E-35 Examination of encapsulation of ADP for preparation of H12-(ADP) liposome (Genki Komakine)

• Presentation No. "Title" (Presenter)
• 2J04 "Development of flexible elastomer nanosheet and their adhesion properties to biological tissue" (Kento Yamagishi)
• 3Pd110 "Preparation of W/O/W emulsion consisting of amino acid headgroup cationic lipid by microfluidic device" (Morihiro Hotta)

• Presentation No. "Title" (Presenter)
• 2C1-43 "The effect of assembling of siRNA and lipids on cellular uptake." (Kohei Onishi)
• 3E4-04 "Fabrication of fluorescent sensor nanosheets for pH mapping." (Daichi Someya)
• 3E4-02 "Development of polymer-nanosheet electrodes for measuring neuronal signals" (Nana Kokubo)
• 3B4-10 "Evaluation of adhesion property of polymer nanosheets to biological tissue surface" (Isao Takahashi)
• 2C1-46 "An evaluation on the binding abilities of H12-liposomes to activated platelets" (Keiko Nakahara)

• "Development of flexible elastomer ultra-thin films with adhesion properties to biological tissue surfaces" (Kento Yamagishi)
• "Sandwich fixation of electronic elements using elastomeric thin films for skin-contact electronics" (Marin Okamoto)
• "The development of ultrathin film strain gauge sensor for analysis of fine skin deformation" (Yuma Tetsu)

• "Application of oxygen micro nano bubble solution for total liquid ventilation"

• "Biopotential Measurement Using Conductive Polymer Nanosheets"
• ○Toshinori Fujie, Kento Yamagishi, Shinji Takeoka

• "Engineered Bio-hybrid Actuators Consisting of Microgrooved Nanosheets and Skeletal Muscle Cells"

• Kento Yamagishi prized "Student Presantation Award"
• "Novel Biomaterials Emerged from Platelet Substitutes Research: Development of Biomedical Nanosheets (Nano-Adhesive Plasters)", (Dr. Toshinori Fujie)
• "Ultra-flexible skin-contact polymer nanosheet electrodes for monitoring of biological signals", (Kento Yamagishi)
• "Evaluation of the hemostatic/rescue effect of resuscitative transfusion using platelet substitute, H12-(ADP)liposomes", (Masato Takikawa)
• "Development of Stem Cells-laden Multilayered Nanosheets for Tissue Defect Repair", (Keisuke Nishiwaki)

• "Study of membrane fusogenicity of amino acid-based cationic liposomes" (Keitaro Homma)
• "The comparison of saturated and unsaturated cationic amino acid lipids for introduction efficiency to cells" (Kohei Onishi)

• Bio-imaging by polymer nanomaterials which sense temperature and oxygen (Shinji Takeoka) Link
• Large-scale fabrication of porous polymer nanosheets in the application of artificial basement membranes for manipulating cells (Toshinori Fujie) Link
• In vitro degradable property of free-standing polymer nanosheets (Yuya Ishizuka) Link
• Evaluation of insulating property of polymer thin films for substrates of multilayered circuits (Marin Okamoto) Link
• Fabrication of stem cell transplantation carrier for tissue defect treatment (Keisuke Nishiwaki) Link
• The development of thin film strain gauge sensor for analysis of skin deformation (Yuma Tetsu) Link

• Yuma Tetsu "The development of thin film strain gauge sensor for analysis of skin deformation" Link

• Kento Yamagishi, Francesco Greco, Shinji Takeoka, and Toshinori Fujie
• "Development of Conductive Polymer Nanosheets for Ultra-Thin Bioelectrodes"

• Stretchable, adhesive and ultra-conformable elastomer thin films
• N. Sato, A. Murata, T. Fujie, S. Takeoka, Soft Matter, in press, DOI:10.1039/C6SM01242F
• Link

• Glue-Free Stacked Luminescent Nanosheets Enable High-Resolution Ratiometric Temperature Mapping in Living Small Animals
• T. Miyagawa, T. Fujie, Ferdinandus, T. T. Vo Doan, H. Sato, S. Takeoka, ACS Applied Materials & Interfaces, in press, DOI: 10.1021/acsami.6b06075
• This paper was highlighted in the ACS Editors' Choice.
• Link

• Large-scale fabrication of porous polymer nanosheets for engineering hierarchical cellular organization
• S. Suzuki, K. Nishiwaki, S. Takeoka, T. Fujie, Advanced Materials Technologies, in press, DOI:10.1002/admt.201600064
• Link

• "title", (Presenter)
• "Roll-to-roll fabrication of conductive polymer nanosheets for the development of ultraconformable skin-contact electrodes", (Dr. Toshinori Fujie)
• "Transfusion with synthetic platelet substitutes, H12-(ADP) liposomes, effectively rescues thrombocytopenic rabbits from massive hemorrhage", (Masato Takikawa)
• "Formulation design of polymer nanosheets for controlled drug release", (Keisuke Nishiwaki)

• Development of free-standing polymer nanosheets for advanced medical and healthcare applications T. Fujie, Polymer Journal (Focus Review), Polymer Journal, 48(7), 773-780 (2016). DOI:10.1038/pj.2016.
• This Focus Review summarizes the recent development of nanosheet technology for biomedical application.
  Cover image was inspired by the night-time sky of July in Japan.
  Title: "Summer Triangle" in Your Hand: an ultra-conformable conductive nanosheet bridging LEDs on the skin.
  This image was designed by Kento Yamagishi, Marin Okamoto, and Daichi Someya.
  Collaborator: Dr. Francesco Greco and Dr. Virgilio Mattoli (Italian Institute of Technology)
• Article / Cover art

• Development of free-standing polymer nanosheets for advanced medical and healthcare applications
• T. Fujie, Polymer Journal (Focus Review), in press, DOI:10.1038/pj.2016.38
• Link

• Title: "Construction of Free-standing Conductive Polymer PEDOT:PSS Nanosheets and Application as Skin Surface Electrodes"
• Authors: Kento Yamagishi, Toshinori Fujie, and Shinji Takeoka (Graduate School of Advanced Science and Engineering, Waseda University)

• Sustainable antimicrobial effect of silver sulfadiazine-loaded nanosheets on infection in a mouse model of partial-thickness burn injury
• Keisuke Ito, Akihiro Saito, Toshinori Fujie, Keisuke Nishiwaki, Hiromi Miyazaki, Manabu Kinoshita,Daizoh Saitoh, Shinya Ohtsubo, Shinji Takeoka
• Acta Biomaterialia
http://www.sciencedirect.com/science/article/pii/S174270611500272X, DOI: 10.1016/j.actbio.2015.05.035

• Synthesis of Phosphorylcholine-Coating Polyimides and the Fabrication of Biocompatible Nanosheets Thereof
• Kohei Asao, Mari Ogino, Atsushi Iwano, Yosuke Okamura, Shinji Takeoka, Yu Nagase
• KOBUNSHI RONBUNSHU (in press)

• Interfacial Effects on the Crystallization and Surface Properties of Poly(L-lactic acid) Ultrathin Films
• Akihiro Udagawa, Toshinori Fujie, Yuko Kawamoto, Akihiro Saito, Shinji Takeoka, Toru Asahi
• Polymer Journal (in press)

• http://www.waseda.jp/top/news/34735 (Japanese)

• http://www.jsap.or.jp/activities/award/lecture/dai39kai.html (Japanese)

• "Title", (Speaker):
  
• 10/31 (9:35AM-),"Ultra-conformable strain gauge for analysis of dynamic skin deformation", (Kento Yamagishi LD3)
  
• 10/31 (13:45- Poster Session),"Fabrication of Metal Lines on Polymer Nanosheets by Inkjet Printer", (Marin Okamoto M1)

• Dr. Toshinori Fujie (Takeoka Group) received "The Young Scientist Lecture Award; The 61st annual Kobe Polymer Research Symposium" from The Society of Polymer Science, Japan (SPSJ), Kansai Regional Chapter (Title: Construction and Functionalization of Polymer Nanosheets for Advanced Medicine).

• Presentation (Poster) Number, "Title", (Speaker)：
• MTLS 759 (Dec.16 7:00pm-9:00pm), "Ultra-conformable polymer nanosheets with inkjet-printed electric circuits", (Marin Okamoto　M1)
• HLTH 272 (Dec 17 4:10pm-4:30pm), "Fabrication of drug crystalline-loaded polymer thin films (nanosheets) for biomedical applications", (Dr. Shinji Takeoka)
• MTLS 1968 (Dec 18 2:05pm-2:25pm), "Microstructured polymer nanosheets for tissue engineering application", (Dr. Toshinori Fujie)
• MTLS 2110 (Dec 18 7:00pm-9:00pm), "Construction of calix crown-containing polymer nanosheets for capturing cesium ion", (Katsunori Sato M2)
• MTLS 2689 (Dec 19 7:00pm-9:00pm), "Roll-to-roll fabrication of conductive polymer nanosheets and their application as skin-contact electrodes", (Kento Yamagishi LD3)

• Title: Advanced Microstructured Biomaterials Interfaced with Living Cells
• IEEE EMBC 2015

• Dr. Toshinori Fujie (Takeoka Group) received "Award for Encouragement of Research in Polymer Science; The Society of Polymer Science, Japan (2015)" from The Society of Polymer Science, Japan (Title: Construction and Functionalization of Free-standing Polymer Nanosheets for Biomedical Application). This award is presented to young scientists under 35 year old, who is actively working in the field of polymer science.
• 高分子学会 高分子研究奨励賞 受賞者 (Japanese)

• 日本化学会第95春季年会 (Japanese)

• 64th SPSJ Annual Meeting

• A ratiometric fluorescent molecular probe for visualization of mitochondrial temperature in living cells
• Homma M., Takei Y., Murata A., Inoue T., Takeoka S.
• Chemical Communications (in press)
• Link

• Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model.
• Taguchi K, Hashimoto M, Ogaki S, Watanabe H, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.
• J. Pharm. Sci. (in press)
• Link

• Date : December 9, 2014
• Location : HongKong
• Development of freestanding microgrooved nanosheets with periosteum-mimetic structure.
• Fujie, T., Shi, X., Ostrovidov, S., Wu, H., Khademhosseini, H., Takeoka, S.

• Date : November 18, 2014
• Location : Tokyo
• 骨膜様微細溝構造を有する高分子ナノシートの開発
• 藤枝 俊宣, Shi Xuetao, Ostrovidov Serge, 武岡 真司, Khademhosseini Ali.

• Date : October 9, 2014
• Location : Tokyo
• Fabrication of Micropatterned Polymeric Nanosheets for Local Delivery of an Engineered Epithelial Monolayer.
• Fujie, T., Mori, Y., Nishizawa, M., Nagai, N., Abe, T., Khademhosseini, A., Kaji, H
• Development of Hierarchical Cellular Organization from Ultra Thin Macroporous Poly(lactic acid) Films.
• Suzuki, S. Fujie, T., Takeoka, S.

• 1. Engineered nanomembranes towards flexible bioelectronics Assist. Prof. Toshinori Fujie
• 2. Size-dependent adhesive strength of poly (DL-lactic acid) nanosheets evaluated by a scratch test with atomic force microscopy Dr. Atsushi Murata, Y. Ishizuka, M. Fujii, T. Kasahara, S. Shoji, J. Mizuno, Y. Honda, S. Takeoka
• 3. Functional liposomes for cancer chemotherapy and immunotherapy Dr. Tianshu Li, S. Takeoka
• 4. In-vitro delivery study of liposomes with monocytes- and bone marrow- derived macrophages Ms. Tan Suyun, S. Takeoka
• 5. Fabrication of conductive PEDOT:PSS nanosheets for skin-contact electrodes Mr. Kento Yamagishi, T. Fujie, S. Takeoka
• 6. Development of an intracellular Cu-free clickable fluorescent probe for living cell imaging Mr. Kazuaki Sawaki, K. Yamagishi, A. Murata, S. Takeoka
• 7. Nutlin3 impact on cancer metabolism of Mdm2 amplification tumor model cells Ms. Aiko Oue, S. Takeoka, T.Graeber

• Link

• Four Takeoka Lab's members presented as follows;
• 1. Engineered nanomembranes for directing cellular organization toward regenerative medicine applications
  ・Dr. Toshinori Fujie, Shoichiro Suzuki, Shinji Takeoka
• 2. Design and synthesis of fluorescent Cu-free clickable probes for specific monitoring of bioactive molecules in living cells
  ・Mr. Kento Yamagishi,Kazuaki Sawaki, Atsushi Murata, Shinji Takeoka
• 3. Construction and evaluation of ratiometric fluorescent probe for mitochondrial temperature imaging
  ・Mr. Mitsumasa Homma, Yoshiaki Takei, Atsushi Murata, Kotaro Oyama, Shinji Takeoka
• 4. Imaging of movement of lipofection using azide modified amino acid-based cationic lipids
  ・Mr. Ryosuke Hokama,Kento yamagishi, Kazuaki Sawaki, Shinji Takeoka

• Professor Takeoka is a chairperson of the organizing committee.
• Date: January 15-16, 2014
• Location: Nisiwaseda Campus Waseda Univerity
• Inhibitory study on the binding of high anionic liposomes to activated platelet membrane Tan Suyun

• A Nanoparticle-Based Ratiometric and Self-Calibrated Fluorescent Thermometer for Single Living Cells
• Yoshiaki Takei, Satoshi Arai, Atsushi Murata, Masao Takabayashi, Kotaro Oyama, Shin’ichi Ishiwata, Shinji Takeoka, and Madoka Suzuki
• ACS NANO (in press)
• Link

• Link

• Dr. Toshinori Fujie developed ultra-thin “carpet” for local cell delivery system in the collaboration with Tohoku University and Harvard University, which reported in Advanced Materials (http://www.wpi-aimr.tohoku.ac.jp/jp/news/press/2013/20131205_000427.html).
  More information (Japanese)

• Dr. Toshinori Fujie received “Japanese and Korean Biomaterials Societies Young Scientist Exchange Program Award (2013)” at the 35th Annual Meeting of the Japanese Society for Biomaterials. This award is presented to young scientists under 35 year, who is actively and internationally working in the field of biomaterials science. Dr. Fujie’s presentation was also selected as “Best Presentation Award” from 5 award winners of the Japanese Society for Biomaterials.

• Date : November 25-26, 2013
• Location : Tower Hall Hunabori
• Local delivery of engineered cell monolayer directed by micropatterned polymeric nanosheets
  Toshinori Fujie, Yoshihiro Mori, Toshiaki Abe, hirokazu Kaji, Ali Khademhosseini
• 創傷被覆材としての医療応用を目的とした抗菌剤担持ナノシートの構築と評価
  伊藤佳祐、齋藤晃広、宮崎裕美、木下学、武岡真司
• マイクロ・ナノバブル分散酸素富化液液を用いた液体換気への応用
  垣内健太、青木順子、針井則一、松田兼一、武岡真司
• 相分離を利用した高分子ナノシートの構築
  藤井麻央、村田篤、齋藤晃広、武岡真司

• Broadcast date : October 27th (Sun), 7:30-8:00
• Link

• Cationic Amino Acid Based Lipids as Effective Non-viral Gene Delivery Vectors for Primary Cultured Neurons
• Yumiko Aoshima, Ryosuke Hokama, Keitaro Sou, Satya Ranjan Sarker, Kabuto Iida, Hideki Nakamura, Takafumi Inoue, and Shinji Takeoka

• A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes
• Tianshu Li, Shinji Takeoka

• Date：October 6, 2013 10:00-17:00
• Place：Sundai cram school, Ochanomizu
• Title：「ナノバイオマテリアルからナノ医療に挑戦する―世界一薄いナノ絆創膏を例に―」
• Link

• Nanosheet Group
• Imaging Group
• Liposome Group

• 高分子ナノシートの新規静脈止血材としての応用
• 齋藤晃広、萩沢康介、木下学、小川大輔、藤枝俊宣、朴栄光、梅津光生、武岡真司
• 9/11 - 13

• Date : 2013/8/28

• Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model.
• Taguchi K, Ujihira H, Watanabe H, Fujiyama A, Doi M, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.

• Homeotropic Alignment of Dendritic Columnar Liquid Crystal Induced by Hydrogen-Bonded Triphenylene Core Bearing Fluoroalkyl Chains
• Shinsuke Ishihara, Yusuke Furuki, Jonathan P. Hill,Katsuhiko Ariga, and Shinji Takeoka

• Development of Latanoprost-Loaded Biodegradable Nanosheet as a New Drug Delivery System for Glaucoma
• Kenji Kashiwagi, Keisuke Ito, Hiroki Haniuda, Shinya Ohtsubo, and Shinji Takeoka

• Tianshu Li and Prof. Takeoka have submitted the article to International Journal of Nanomedicine and it has accepted.
• A novel application of maleimide for advanced drug delivery: In vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes
  Tianshu Li, Shinji Takeoka

• Date: June 23
  13:00-14:00
  Presenter: Tianshu Li
  Title: Study of Advanced Drug Delivery of Liposomes by Maleimide Modification
  
• Date: June 23
  14:00-15:00
  Presenter: Akihiro Saito
  Title: Development of Polymer Nanosheet for Wound Dressing Materials
  

• 自己支持性高分子ナノシートの物性と医療応用　―ミクロ相分離構造を利用した機能化―
• Link

• Waseda University and National Defense Medical College have developed revolutionary "nano plaster" for surgery.
• Link

• Mami Doi, Atsushi Fujiyama, Yasuo Ikeda, Shinji Takeoka have submitted the article to Drug Metabolism ＆ Disposition and it has accepted.
• Pharmacokinetic Study of the Structural Components of Adenosine Diphosphate-encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute
• Kazuaki Taguchi, Hayato Ujihira, Shigeru Ogaki, Hiroshi Watanabe, Atsushi Fujiyama, Mami Doi, Yosuke Okamura, Shinji Takeoka, Yasuo Ikeda, Makoto Handa, Masaki Otagiri, and Toru Maruyama

• Doi ： Evaluation of Physical Properties and Hemostatic Ability of H12-(ADP)liposome as Artificial Platelet.(Review by the administration after hemorrhage)
• Hokama ： 細胞への生体高分子運搬体としてのカチオン性アミノ酸型脂質リポソームの構築評価
• Suzuki ： 高親水性ナノシート(CaAlg ナノシート)の構築および評価

• Link

• Link

• The article was accepted in Chemical Communications. Yoshiaki Takei, Atsushi Murata, Kento Yamagishi, Satoshi Arai, Hideki Nakamura, Takafumi Inoue and Shinji Takeoka have submitted the article to Chemical Communications and it has accepted.
• Intracellular click reaction with a fluorescent chemical Ca2+ indicator to prolong its cytosolic retention
• Yoshiaki Takei , Atsushi Murata , Kento Yamagishi , Satoshi Arai , Hideki Nakamura , Takafumi Inoue and Shinji Takeoka

• The article was accepted in JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS. Daisuke Niwa, Masatsugu Koide, Toshinori Fujie, Nobuhito Goda, Shinji Takeoka have submitted the article to JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS and it has accepted.
• Application of nanosheets as an anti-adhesion barrier in partial hepatectomy
• Daisuke Niwa, Masatsugu Koide, Toshinori Fujie, Nobuhito Goda, Shinji Takeoka*

• Prof. Takeoka, Li, Saito give research reports at TWIns 5 years anniversary joint symposium (April 20, TWIns).
• Prof. Takeoka：医用高分子からなるナノシートを用いた"機能性ナノ絆創膏"としての研究展開 (Research development as "functional nano plaster" using medical polymer nanosheet.)
• Saito：Evaluation of therapeutic efficiency of antibiotic-loaded nanosheet in a　murine burn-wound infection model.
• Li：Preparation and biological evaluation of maleimide-modified liposomes for　advanced drug delivery.

• Li and Prof. Takeoka gave a research report at 245th American Chemical Society National Meeting and Exposition (April 7-8, New Orleans)
• Fabrication methods of free-standing porous polymer thin films. H.Zhang, N. Takamizawa, S. Takeoka
• In vitro and in vivo evaluation of maleimide-modified liposome for drug delivery. T. Li, S. Takeoka

• The article was accepted in Journal of Vascular Surgery. The article was accepted in Journal of Vascular Surgery. Akihiro Saito, Toshinori Fujie, and Shinji Takeoka have submitted the articles to Journal of Vascular Surgery.
• Effective control of massive venous bleeding by "multi-overlapping therapy" using polysaccharide nanosheets in a rabbit inferior vena cava injury model
• Kosuke Hagisawa, Akihiro Saito, Manabu Kinoshita, Toshinori Fujie, Naoki Otani, Satoshi Shono, Young-Kwang Park, and Shinji Takeoka

• The article was accepted in International Journal of Nanomedicine. Satya Ranjan Sarker, Yumiko Aoshima, Ryosuke Hokama, Keitaro Sou, and Shinji Takeoka have submitted the articles to International Journal of Nanomedicine.
• Arginine-based cationic liposomes for efficient in vitro plasmid DNA delivery with low cytotoxicity
• Satya Ranjan Sarker, Yumiko Aoshima, Ryosuke Hokama, Takafumi Inoue, Keitaro Sou, Shinji Takeoka

• The article was accepted in Journal of Maclomolecules. Dr. T. Fujie, Yuko Kawamoto, Hiroki Haniuda, Akihiro Saito, and Shinji Takeoka have submitted the article to Journal of Macromolecules and it has accepted.
• Selective molecular permeability induced by glass transition dynamics of semicrystalline polymer ultrathin films
• Toshinori Fujie, Yuko Kawamoto, Hiroki Haniuda, Akihiro Saito, Koki Kabata, Yukio Honda, Eriko Ohmori, Toru Asahi, and Shinji Takeoka

• The article was accepted in Journal of Clinical Neuroscience Corresponding. A Saito, Dr. T. Fujie, and Prof. S. Takeoka have submitted the article to Journal of Clinical Neuroscience Corresponding and it has accepted. This work was done with National diffence medical college.
• Novel therapeutic use of polysaccharide nanosheets for arachnoid plasty and enhancement of venous tensile strength in rat microneurosurgery
• Naoki Otani, Manabu Kinoshita, Toshinori Fujie, Akihiro Saito, Shinji Takeoka, Daizoh Saitoh, Kohsuke Hagisawa, Hiroshi Nawashiro, Katsuji Shima

• Our research about "Nanothermometer" was pressed on Nikkei newsppaper. This work was done with Ishiwata lab (Waseda Univ. Dept. Phys.) and WABIOS.
• 【Development of "Nanothermometer" for the first time in the world to measure the slight temperature change in cells】

• Our research about "fragmented nanosheet" was introduced on Wiley-VCH ChemistryViews.

• Our research about "fragmented nanosheet" was introduced on Wiley Japan Science Cafe.

• Dr. Okamura, K. Kabata, A. Saito & Prof. S. Takeoka has submitted the article to Advanced Materials and it was accepted.
• Fragmentation of Poly(lactic acid) Nanosheets and Patchwork Treatment for Burn Wounds
• Yosuke Okamura, Koki Kabata,Manabu Kinoshita,Hiromi Miyazaki,Akihiro Saito,Toshinori Fujie,Shinya Ohtsubo,Daizoh Saitoh,Shinji Takeoka,

• Katsuno S, Doi M & Prof. S. Takeoka has submitted the article to J. Thromb. Haemostasis and it was accepted.
• Fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage
• Nishikawa K, Hagisawa K, Kinoshita M, Shono S, Katsuno S, Doi M, Yanagawa R, Suzuki H, Iwaya K, Saitoh D, Sakamoto T, Seki S, Takeoka S, Handa M. J. Thromb. Haemostasis, 10(10), 2137-2148(2012)

• Dr. S. Arai, S. Hirosawa, Dr. A. Murata & Prof. S. Takeoka has submitted the article to ACS Comb.Chem. and it was accepted.
• Mass Spectrometric Screening of Ligand with Lower Off-rate from a Clikced-based Pooled Library
• Arai, S.; Hirosawa, S.; Oguchi, Y.; Suzuki, M.; Murata, A.; Ishiwata, S.; Takeoka, S. ACS Comb.Chem., 14, 451-455(2012)

• S. Hirosawa, Dr. S. Arai & Prof. S. Takeoka has submitted the article to Chemical communications and it was accepted.
• A TEMPO-Conjugated Fluorescent Probe for Monitoring Mitochondrial Redox Reactions.
• S. Hirosawa, S. Arai, S. Takeoka Chemical communications, in press (2012)

• Our research about "Walking Nanothermometer"(Imaging-group) was pressed on some journals. This work was done with Ishiwata lab (Waseda Univ. Dept. Phys.) and WABIOS
• 【Walking Nanothermometer】 Waseda Univ.HP(in Japanese)

• M. Takabayashi, Y. Takei, Dr. S. Arai & Prof. S. Takeoka has submitted the article to Lab on a chip and it was accepted
• Walking nanothermometers: Spatiotemporal temperature measurement of transported acidic organelles in single living cells.
• K. Oyama, M. Takabayashi, Y. Takei, S. Arai, S. Takeoka, S. Ishiwata, M. Suzuki Lob on a chip, in press (2012)

• A. Saito, Dr. T. Fujie & Prof. S. Takeoka has submitted the article to Wound Repair and Regeneration and it was accepted
• An ultra-thin poly(L-lactic acid) nanosheet as a burn-wound dressing for protection against bacterial infection.
• Hiromi Miyazaki, Manabu Kinoshita, Akihiro Saito, Toshinori Fujie, Koki Kabata, Etsuko Hara, Satoshi Ono, Shinji Takeoka, Daizoh Saitoh Wound Repair and Regeneration, in press (2012)

Takeoka Laboratory, Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University
2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan. Twins 2F Open-Lab / Tel&Fax 03-5369-7324